The weather is usually not terribly cold, although being outside all day makes you feel the chill, so wear your water-resistant jacket, with a heavy wool sweater.Average temperature in Rome in January and February: 8 °C / 46 °F.
Here is my itinerary for a 10-day road trip in Tuscany, Italy, with visits to some of the top sights, as well as the exploration of less touristy spots.